ABSTRACT
Abstract: Several reports have demonstrated difficulties and lack of agreement in the histopathological diagnosis of particular melanocytic lesions, with problems in their management. A histogenetic approach to the study of these lesions originated the following classification: 1. superficial atypical proliferation significance; 2. melanocytic tumor of uncertain potential; 3. pigmented epithelioid melanocitoma of uncertain potential; 4. microinvasive radial growth phase of uncertain potential. The terminology remains controversial, reflecting the uncertainty of the diagnosis and the biological potential of these atypical melanocytic lesions.
Subject(s)
Humans , Skin Neoplasms/diagnosis , Melanocytes/pathology , Melanoma/diagnosis , Nevus, Pigmented/diagnosis , Precancerous Conditions , Skin Neoplasms/classification , Diagnosis, Differential , Melanoma/classification , Nevus, Pigmented/classification , Terminology as TopicABSTRACT
Coexistence of atypical adenoma, adenoma with bizarre nuclei and follicular variant of papillary carcinoma is described in the same thyroid, with study of p53 expression. A 72-year-old woman presented to the endocrinology outpatient unit for a routine follow-up visit. Patient underwent a total thyroidectomy. Histological examination revealed a solid nodular neoplasm with the longest diameter of 0.8 cm in the upper pole of the left lobe. The neoplasm showed the histological features of follicular variant of papillary carcinoma with moderate diffuse immunoreactivity for p53. The lower pole of the right lobe showed two adjacent nodules with histological features respectively of atypical adenoma and adenoma with bizarre nuclei, with strong diffuse immunoreactivity for p53.
Subject(s)
Aged, 80 and over , Female , Gastric Mucosa/cytology , Histocytochemistry , Humans , Metaplasia/pathology , Microscopy , Vacuoles/pathologySubject(s)
Aged , Biopsy , Calcinosis/diagnosis , Histocytochemistry , Humans , Immunohistochemistry , Laparoscopy , Male , Mesothelioma/diagnosis , Mesothelioma/pathology , Microscopy , Peritoneal Neoplasms/diagnosis , Peritoneal Neoplasms/pathology , Radiography, Abdominal , Tomography, X-Ray ComputedABSTRACT
Case Report: We report the case of an oncocytic sialolipoma of the submandibular gland with sebaceous differentiation in a 73-year-old man. The initial symptom was a right submandibular painless mass. Ultrasonography showed a hypoechoic oval mass posterior to the submandibular gland. The tumorectomy was performed with preservation of the salivary gland. The tumor was composed of mature adipose tissue surrounded by a thin fibrous capsule, multiple nodules of oncocytes, normal ductal-acinar units with focal ductal sebaceous differentiation. Discussion: We reviewed literature of the reported cases of mixed tumors of the salivary glands composed of mature adipose tissue with oncocytosis, salivary ducts, and acini with sebaceous differentiation. Conclusions: Sialolipoma and lipoadenoma with or without oncocytosis and/or sebaceous differentiation should be considered organ-specific tumors with a distinct histological appearance and specific terminology.